In the last three seasons, Inter have won the Champions League, the Coppa Italia and the Europa League, with an average of 6-1-2.
This is the second year Inter have qualified for the Champions Cup, having lost in the quarter-finals in 2013.
They’ve been on a run of winning the league for a year now, having won the Coppio in the same period.
Inter are still favourites to finish second, but will need a very good start to get their foot in the Champions league.
They will also face Juventus in the last 16, who have beaten Inter at the Stadio Olimpico twice before, and have won it once in the league.
This fixture will be the first of the two Champions League matches in Italy since August 2019.
What will be on the pitch?
Inter have lost the first two Serie A matches, but the Nerazzurri have won six in a row and the last four in the Nerazu Stadium.
The Nerazul have won nine of their last 10 league matches.
They are unbeaten in all competitions in Serie A, including a 1-0 victory over Sampdoria in the derby in the second leg of the final.
What to watch for: The Nerazzul have had a good start, winning the opening two matches of the season and have scored four goals.
But the Neras are not known for their defensive ability and have conceded eight goals in Serie B. This could be a very difficult match for them, as they have a very strong team in front of them, and this will be their first meeting since January.